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Scientific studies
Peer-reviewed research on ketosis, fasting, and metabolic health from scientists and physicians around the world. A curated library of links to studies referenced in the documentary and beyond.
Work in progress — bookmark this page and check back regularly
01 cancer
Dr. Thomas Seyfried — Cancer as a Metabolic Disease (2017)
Foundational paper reframing cancer as a metabolic disorder rather than a purely genetic one, with implications for ketogenic therapy.
pmc.ncbi.nlm.nih.gov/articles/PMC5324220
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Greek GBM study — 18 patients on a ketogenic diet
Clinical study from Greece following 18 glioblastoma (GBM) patients implementing a ketogenic diet as part of their treatment protocol.
frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1489812
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02 heart disease
Katarzyna Kowalcze (2024) — Keto vs heart disease
Examines the relationship between ketogenic dietary patterns and cardiovascular disease markers.
mdpi.com/2072-6643/15/15/3368
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Kaja Falkenhain — Influence of the keto diet on lipids
Investigates how a ketogenic diet impacts lipid profiles, with relevance to cardiovascular health and disease risk.
sciencedirect.com/science/article/pii/S0002916522004749
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Dr. McCommis (St. Louis University) — Keto & heart failure
Mechanistic study on the effects of a ketogenic diet on heart failure outcomes and cardiac metabolism.
nature.com/articles/s42255-020-00296-1
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03 visceral fat
Mingqian He — Intermittent fasting + low-carb vs visceral fat
Randomized controlled trial (n=158 adults with metabolic syndrome) comparing an 8-hour time-restricted eating window, a low-carbohydrate diet, their combination, and a control over 3 months. Focus on body composition and cardiometabolic markers.
pmc.ncbi.nlm.nih.gov/articles/PMC9589024
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Ketogenic Metabolic Therapies in prevention & treatment of non-communicable diseases
Broad review covering the role of ketogenic metabolic therapies across a range of chronic, non-communicable diseases.
frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1629921
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Carbohydrate-restricted diets & macronutrient replacements — Meta-analysis
Meta-analysis of randomized trials investigating different carbohydrate-restricted diet types and macronutrient replacements for metabolic health in adults.
pubmed.ncbi.nlm.nih.gov/41004974
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Carb-restricted diets & cardiovascular health — Meta-analysis
Meta-analysis of randomized trials on the effects of carbohydrate-restricted diets and macronutrient replacements on cardiovascular health and body composition in adults.
pubmed.ncbi.nlm.nih.gov/40935153
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